Proper calibration of the Filament Profile is essential for good prints. Orca slicer has several built in calibration tests to assist in determining the specific profile values.
Specifically you should calibrate for each of your filaments:
A great guide that would be hard to do better in terms of explanations is at https://www.obico.io/blog/orcaslicer-comprehensive-calibration-guide/
For calibrating flow rate, I prefer the following calibration test over the Orca test as it’s less subjectively focused and more functionality focused, uses way less filament and prints quicker: https://www.printables.com/model/1113488-flexi-flow-calibration-tool-v4-by-ck3d
Additionally you may want to perform some experiments to address overhang and bridging settings.
https://www.youtube.com/watch?v=7rNlBwYd30k
Covers temp towers, string/retraction calibration, running the Orca test cube, and calibrating max volumetric flow rate.
https://www.youtube.com/watch?v=g8kNuXuziCc
Covers temp towers, Orca's filament flow ratio calibration test, pressure advance, string/retratction calibration, and vertical fine artifact test